Junsuk Lee

VIPerturb-seq enables genome-wide CRISPR perturbation screens using probe-based detection, improving throughput and efficiency for single-cell analysis.

FX-seq improves snRNA-seq from FFPE and PFA-fixed tissues by removing crosslinks and preventing RNA leakage, enabling analysis of 321,710 nuclei from mouse and human samples.

This paper introduces RNA fingerprinting, a method to map transcriptional responses to perturbations using reference dictionaries, showing accurate single-cell assignments and broad biological applications.