Yifang Liu

The paper develops a multi-scale kinetic model and advanced assays to assess mRNA-LNP potency by integrating mechanistic understanding with multi-omics data.

NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis by using reversible crosslinkers and amplified FISH signals.

The paper maps pseudouridylation sites in human cell lines using nanopore sequencing and shows how psi modifications affect translation through distinct mechanisms.