Keqing Nian

This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.

NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis by using reversible crosslinkers and amplified FISH signals.

This study uses direct RNA sequencing to examine pseudouridylation dynamics in neurons under healthy and unhealthy conditions, finding changes in psi writer expression and site occupancy.

This paper develops a cell-free method to directly measure infectious viral titer by capturing intact virions with an aptamer and detecting their genomes using FISH.

The paper develops a DNA-enhanced CuAAC ligand for intracellular biomolecule labeling in live cells, demonstrating reduced copper toxicity and effective labeling.