Author

Amber M. Amparo

University of North Carolina at Chapel HillORCID 0000-0003-3805-746XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Channing J. DeriD· 2 shared Clint A. StalneckeriD· 2 shared Kristina Drizyte‐MilleriD· 2 shared A. Cole EdwardsiD· 1 shared Adrienne D. CoxiD· 1 shared Álvaro Curiel‐GarcíaiD· 1 shared Amanda R. Decker-FarrelliD· 1 shared Andrea CalifanoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Channing J. DerORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 3, 2025

Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance

Kristina Drizyte‐Miller, Seamus E. Degan, Ryan D. Mouery…·Channing J. Der

This study shows that ONC201 inhibits KRAS-mutant pancreatic cancer growth and overcomes resistance to RAS inhibitors by activating ClpP and altering metabolic pathways.

3 citations

humanexperimental assay

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Cancer BiologyNaturePeer-reviewedApr 8, 2024

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

Urszula N. Wasko, Jingjing Jiang, Tanner C. Dalton…·Kenneth P. Olive

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

225 citationstop 1%

humanmouse

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