Author
University of North Carolina at Chapel HillORCID 0000-0002-4901-2454Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Yan Ming Ching, Shruthi Narayanan, Jeffrey A. Klomp…·Bjoern Papke
This study shows that combining AXL inhibition with RAS or ERK inhibitors enhances efficacy in KRAS-mutant cancers by overcoming resistance mechanisms.
Wen-Hsuan Chang, Alec J. Vaughan, Addison G. Stamey…·Channing J. Der
This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.
Kristina Drizyte‐Miller, Seamus E. Degan, Ryan D. Mouery…·Channing J. Der
This study shows that ONC201 inhibits KRAS-mutant pancreatic cancer growth and overcomes resistance to RAS inhibitors by activating ClpP and altering metabolic pathways.
Katherine H. Pedone, Vanessa González‐Pérez, Luciana E. Leopold…·David J. Reiner
The paper engineers threshold-based selection systems in C. elegans to identify novel downstream effectors by disrupting embryonic morphogenesis with conditional CED-10/Rac activation.