BioinformaticsbioRxivPreprint
A comparison between Greengenes, SILVA, RDP, and NCBI reference databases in four published microbiota datasets
Camilla Ceccarani, Marco Severgnini
This paper compares four 16S rRNA reference databases (Greengenes, SILVA, RDP, NCBI) across four microbiota datasets, finding that while alpha- and beta-diversity vary, the ability to detect experimental group differences remains consistent across databases.