Kenneth G. C. Smith

This study shows that elderly individuals vaccinated against SARS-CoV-2 maintain neutralizing antibodies against recent variants, with reduced immune imprinting from ancestral variants after booster doses.

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

This paper identifies common-variant associations with selective IgA deficiency using GWAS meta-analysis and pleiotropy-based methods, finding 26 variants outside the MHC and highlighting polygenic and immune-related biology.

This study uses whole-genome sequencing in a national healthcare system to diagnose rare diseases and discover new aetiological variants, identifying 95 Mendelian associations and 4 novel non-coding disease-causing variants.

The paper identifies a causal variant in a super-enhancer that disrupts an NF-κB regulatory circuit, leading to T-cell activation in immune-mediated diseases.

The paper introduces a method to reduce dimensions of GWAS summary data for related traits, identifying genetic risk patterns and enabling functional characterisation of components.

This paper develops and validates a 17-gene qPCR classifier in whole blood that stratifies IBD patients into prognostic subgroups without requiring cell separation.

The paper introduces a diagnostic gene panel called GRID for primary immunodeficiencies, showing high sensitivity and specificity in identifying genetic variants across 279 genes.

This study identifies genetic subsets of EGPA associated with asthma and eosinophil levels, revealing two distinct clinical and genetic syndromes.