Abigail F. Groff

The paper shows that the inactive X chromosome modulates the expression of the active X chromosome in humans, affecting 38% of X-linked genes and contributing to sex differences in disease.

The paper identifies a causal variant in a super-enhancer that disrupts an NF-κB regulatory circuit, leading to T-cell activation in immune-mediated diseases.

The paper identifies Tug1 as essential for male fertility, showing it has three distinct regulatory activities: a cis DNA repressor, a trans-acting lncRNA, and a conserved peptide affecting mitochondrial function.