Paul Lyons

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

This paper identifies common-variant associations with selective IgA deficiency using GWAS meta-analysis and pleiotropy-based methods, finding 26 variants outside the MHC and highlighting polygenic and immune-related biology.

The paper reports genotyping and population structure findings from the China Kadoorie Biobank, revealing relatedness, consanguinity, and population movement patterns.

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

The paper introduces MAGAR, a framework to identify methylation quantitative trait loci (methQTLs) and distinguish common from cell-type-specific effects using DNA methylation and genotyping data.

The paper introduces a method to reduce dimensions of GWAS summary data for related traits, identifying genetic risk patterns and enabling functional characterisation of components.

This paper develops and validates a 17-gene qPCR classifier in whole blood that stratifies IBD patients into prognostic subgroups without requiring cell separation.

This study identifies genetic subsets of EGPA associated with asthma and eosinophil levels, revealing two distinct clinical and genetic syndromes.