Author

David Ontoso

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-3831-178XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Scott KeeneyiD· 2 shared Aidin Shabro· 1 shared John C. DittmariD· 1 shared John L. NitissiD· 1 shared Kaixian LiuiD· 1 shared Lyuqin Zheng· 1 shared Meret ArteriD· 1 shared Monika MehtaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Scott KeeneyORCID

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2 papers

Recent·Most cited

GeneticsProceedings of the National Academy of SciencesPeer-reviewedSep 1, 2026

A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage

David Ontoso, Monika Mehta, Aidin Shabro…·Scott Keeney

The paper develops hypercleavage TOP2 mutants in yeast, human, and mouse to study TOP2-mediated DNA damage and toxicity, showing their utility in genetic screens and in vivo models.

DOI 10.1073/pnas.2616452123

yeasthuman

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BiochemistryNaturePeer-reviewedFeb 19, 2025

Reconstitution of SPO11-dependent double-strand break formation

Zhi Zheng, Lyuqin Zheng, Meret Arter…·Scott Keeney

This study reconstitutes SPO11-dependent DNA double-strand break formation in vitro, revealing dimerization-dependent cleavage and topoisomerase activity.

40 citationstop 1%

mouseDNA methylation

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