Lorena Espinar

This study identifies cell cycle-dependent nuclear phosphatidylinositol metabolism and its impact on histone methylation and heterochromatin states.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.

The paper shows that strand asymmetry affects mismatch resolution during single-strand annealing in mouse chromatin, with the break position determining the repair bias.

The paper experimentally assays a fitness landscape on a macroevolutionary scale by analyzing the effects of amino acid substitutions in yeast His3 orthologs.

The paper shows that promoter architecture influences co-translational regulation of mRNA levels, with Dbp2 mediating reduced regulation in inducible promoters and ORF sequence playing a major role in constitutive genes.