Sara Sdelci

The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.

This study identifies cell cycle-dependent nuclear phosphatidylinositol metabolism and its impact on histone methylation and heterochromatin states.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

Machine learning integration of over 25,000 mass spectrometry experiments yields 15,326 human protein complexes covering 13,769 proteins, plus 511 AlphaFold-derived mutually exclusive subunit pairs.

The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

The paper introduces a workflow for IP-MS data to detect differentially present bait proteoforms, offering insights into protein function through peptidoform analysis.

The paper identifies widespread metabolic enzyme localization on chromatin in healthy and cancer cells, showing tissue-specific abundance and non-canonical roles in DNA damage and repair.

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.