Thomas E. Wellems

This study examines morphological changes in apicoplasts of P. falciparum persisters after drug treatment, finding that apicoplasts become enlarged and irregularly shaped during dormancy, with variations in shape and positioning over time.

This study uses long-read scRNA-seq to characterize full-length transcripts of Plasmodium vivax, revealing isoform diversity and developmental regulation.

The paper introduces Corticall, a graph-based method to detect de novo mutations using short-read and long-read data, validated on Plasmodium falciparum crosses.

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.