Author

Christopher G. Jacob

Centre for Human Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexander Egyir-YawsoniD· 1 shared Alistair MilesiD· 1 shared Anastasia Hernández-KoutouchevaiD· 1 shared Anna E. JeffreysiD· 1 shared Arjèn E. van’t HofiD· 1 shared Calvin Yee· 1 shared Chanaki Amaratunga· 1 shared Christina HubbartiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenomics

Alexander Egyir-YawsonORCID

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2 papers

Recent·Most cited

Targeted genomic surveillance of insecticide resistance in African malaria vectors

Sanjay Curtis Nagi, Eric R. Lucas, Faisal Ashraf, Trevor Mugoya, Edward Lukyamuzi, Shannan Summers, Calvin Yee, Christopher G. Jacob, Harun Njoroge, Thomas Pemberton, John Essandoh, Martin Lukindu, Honorine Kaboré, Grégoire Sawadogo, Jessica Williams, , Martin J. Donnelly

This paper develops a targeted genomic surveillance approach for insecticide resistance in malaria vectors, identifying resistance variants and demonstrating predictive modeling with high accuracy.

bioRxiv · Feb 14, 2025 · PreprintGenomics

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Christopher G. Jacob, Megan R. Ansbro, Roberto Amato, Mihir Kekre, Ranitha Vongpromek, Mehul Dhorda, Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Olivo Miotto, Rick M. Fairhurst, Thomas E. Wellems, Dominic P. Kwiatkowski

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.

Malaria Journal · May 13, 2020Peer-reviewedGenetics