Author

Chanaki Amaratunga

Cambodia National Malaria Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 1 Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Olivo MiottoiD· 3 shared Abul Faiz· 2 shared Aung Pyae PhyoiD· 2 shared Mallika ImwongiD· 2 shared Mayfong MayxayiD· 2 shared Mehul DhordaiD· 2 shared Mihir Kekre· 2 shared Rick M. Fairhurst· 2 shared

Activity by Year

2015-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersSystems Biology

Olivo MiottoORCID

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Author profile →

4 papers

Recent·Most cited

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Henry Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank M. Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, , Zbynek Bozdech

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

bioRxiv · May 17, 2021 · PreprintSystems Biology

Analysis of Plasmodium vivax schizont transcriptomes from field isolates reveals heterogeneity of expression of genes involved in host-parasite interactions

Sasha V. Siegel, Lia Chappell, Jessica B. Hostetler, Chanaki Amaratunga, Seila Suon, Ulrike Böhme, Matthew Berriman, Rick M. Fairhurst, Julian C. Rayner

This study analyzes P. vivax schizont transcriptomes from field isolates, revealing gene expression heterogeneity and identifying genes involved in host-parasite interactions.

Scientific Reports · Oct 7, 2020Peer-reviewedGenomics

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Christopher G. Jacob, Megan R. Ansbro, Roberto Amato, Mihir Kekre, Ranitha Vongpromek, Mehul Dhorda, Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Olivo Miotto, Rick M. Fairhurst, Thomas E. Wellems, Dominic P. Kwiatkowski

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.

Malaria Journal · May 13, 2020Peer-reviewedGenetics

Genomic epidemiology of the current wave of artemisinin resistant malaria

Roberto Amato, Olivo Miotto, Charles Woodrow, Jacob Almagro-Garcia, Ipsita Sinha, Susana Campino, Daniel Mead, Eleanor Drury, Mihir Kekre, Mandy Sanders, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Tim J C Anderson, Voahangy Andrianaranjaka, , MalariaGEN Plasmodium falciparum Community Project

This study identifies kelch13 mutations associated with artemisinin resistance in Southeast Asia and finds low frequency of these mutations in Africa, suggesting different evolutionary pressures.

bioRxiv · May 24, 2015 · PreprintEvolutionary Biology