GeneticsbioRxivPreprint
Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species
Mara Neuerburg, Larissa Smulders, Erik B. van den Akker…·Joris Deelen
This study identifies rare genetic variants in the IIS/mTOR pathway in long-lived humans and shows they have shared functional effects on lifespan-related traits in mice.
DOI 10.64898/2026.05.28.728260