Matthias Klein

This study identifies macrophage-mediated cytokine activation of T cells in varicose veins, highlighting a potential therapeutic target for chronic venous insufficiency.

This study shows that E-cadherin in oral Langerhans cells maintains dendritic morphology and microbiota-dependent immune homeostasis, preventing dysbiosis and inflammation.

The paper identifies oligodendrocyte subtype changes in Parkinson's disease across species, linking them to disease progression and clinical outcomes.

This study identifies kinome activity and transcriptomic changes in human neutrophils after TREM-1 activation, revealing potential kinase targets for inflammatory and cancer therapies.

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

This paper shows menin inhibitors increase CLEC12A expression in AML, making it more responsive to CLEC12A-targeted CAR T cells, improving treatment outcomes.

This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.