Author

Dirk Matthes

Max Planck Institute for Multidisciplinary SciencesORCID 0000-0003-3969-6335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Benedikt FriegiD· 3 shared Christian DienemanniD· 3 shared Christian GriesingeriD· 3 shared G.F. SchroederiD· 3 shared Loren B. AndreasiD· 3 shared Stefan BeckeriD· 3 shared Andrei LeonoviD· 2 shared Armin GieseiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Benedikt FriegORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 30, 2025

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ fibrils and modulates fibril formation.

Mookyoung Han, Benedikt Frieg, Dirk Matthes…·Christian Griesinger

This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

DOI 10.1101/2025.05.30.655790

humanstructural biology

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BiochemistrybioRxivPreprintApr 21, 2025

Structural insight into binding of novel PET tracer MODAG-005 to lipidic ????-Synuclein fibrils

Myeongkyu Kim, Dirk Matthes, Benedikt Frieg…·Christian Griesinger

This study identifies two binding sites of the PET tracer MODAG-005 on lipidic α-synuclein fibrils, with the cavity site being more stable and selectively occupied under certain conditions.

1 citation

humanstructural biology

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Molecular BiologyNature CommunicationsPeer-reviewedNov 10, 2022

The 3D structure of lipidic fibrils of α-synuclein

Benedikt Frieg, Leif Antonschmidt, Christian Dienemann…·G.F. Schroeder

The paper presents six atomic structures of α-synuclein fibrils in the presence of phospholipids, revealing how phospholipids influence fibril morphology and lipid interactions.

101 citationstop 1%

protein structureexperimental assay

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