Author

Burcu Bestas

AstraZeneca (Sweden)ORCID 0000-0003-3990-1909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Marcello MarescaiD· 2 shared Mike A. Firth· 2 shared Nina Akrap· 2 shared Pei-Pei Hsieh· 2 shared Sandra WimbergeriD· 2 shared Saša ŠvikovićiD· 2 shared Songyuan LiiD· 2 shared Amir Taheri‐GhahfarokhiiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Marcello MarescaORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedAug 14, 2023

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth…·Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

137 citationstop 1%

CRISPR screenexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedMar 24, 2022

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li…·Marcello Maresca

This paper develops two prime editing strategies using DSB repair to improve genomic insertion efficiency and purity, expanding the prime editing toolkit.

54 citations

experimental assaydrug response / drug discovery

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