Author

Pei-Pei Hsieh

AstraZeneca (Sweden)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Assay:CRISPR screen· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Marcello MarescaiD· 4 shared Nina Akrap· 4 shared Martin PeterkaiD· 3 shared Sandra WimbergeriD· 3 shared Saša ŠvikovićiD· 3 shared Anders LundiniD· 2 shared Burcu BestasiD· 2 shared Euan Gordon· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMolecular Biology

Marcello MarescaORCID

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Author profile →

4 papers

Recent·Most cited

Artemis Regulates Homology-Independent Prime Editing (PRINS) for Enhanced Genomic Insertions

Louis C. Dacquay, Oi Kuan Choong, Angela Membrino, Anders Lundin, Nina Akrap, Johannes Köllner, Pei-Pei Hsieh, Anna Baran, Euan Gordon, Salman Mustfa, Sabina Saka, Danang Crysnanto, Fredrik Karlsson, Anders Dahlen, George Thom, , Marcello Maresca

This study identifies Artemis as a regulator of PRINS editing, showing that modulating Artemis improves insertion efficiency and specificity for genomic engineering.

bioRxiv · Jan 9, 2026 · PreprintMolecular Biology

Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering

Panagiotis Antoniou, Louis Dacquay, Niklas Selfjord, Katja Madeyski-Bengtson, Anna-Lena Loyd, Euan Gordon, George Thom, Pei-Pei Hsieh, Sandra Wimberger, Saša Šviković, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.

bioRxiv · Feb 1, 2024 · PreprintBioengineering

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, , Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

Nature Communications · Aug 14, 2023Peer-reviewedMolecular Biology

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Dmitrii Degtev, Burcu Bestas, Jack Barr, Stijn van de Plassche, Patricia Mendoza-García, Saša Šviković, Grzegorz Sienski, Mike A. Firth, Marcello Maresca

This paper develops two prime editing strategies using DSB repair to improve genomic insertion efficiency and purity, expanding the prime editing toolkit.

Nature Communications · Mar 24, 2022Peer-reviewedMolecular Biology