Author

Songyuan Li

AstraZeneca (Sweden)ORCID 0000-0003-2085-9253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Burcu BestasiD· 2 shared Marcello MarescaiD· 2 shared Mike A. Firth· 2 shared Nina Akrap· 2 shared Pei-Pei Hsieh· 2 shared Sandra WimbergeriD· 2 shared Saša ŠvikovićiD· 2 shared Amir Taheri‐GhahfarokhiiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Burcu BestasORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedAug 14, 2023

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth…·Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

137 citationstop 1%

CRISPR screenexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedMar 24, 2022

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li…·Marcello Maresca

This paper develops two prime editing strategies using DSB repair to improve genomic insertion efficiency and purity, expanding the prime editing toolkit.

54 citations

experimental assaydrug response / drug discovery

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GenomicsCell Reports MethodsPeer-reviewedAug 1, 2021

Using targeted genome integration for virus-free genome-wide mammalian CRISPR screen

Kai Xiong, Karen Julie la Cour Karottki, Hooman Hefzi…·Lasse Ebdrup Pedersen

This paper develops a virus-free CRISPR screening platform for CHO cells, identifying 338 essential genes and 76 genes involved in ER stress.

38 citations

mouseCRISPR screen

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