Author

Saša Šviković

AstraZeneca (Sweden)ORCID 0000-0002-4149-8453Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Marcello MarescaiD· 3 shared Nina Akrap· 3 shared Pei-Pei Hsieh· 3 shared Sandra WimbergeriD· 3 shared Burcu BestasiD· 2 shared Julian E. SaleiD· 2 shared Martin PeterkaiD· 2 shared Mike A. Firth· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Marcello MarescaORCID

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Author profile →

5 papers

Recent·Most cited

Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering

Panagiotis Antoniou, Louis Dacquay, Niklas Selfjord, Katja Madeyski-Bengtson, Anna-Lena Loyd, Euan Gordon, George Thom, Pei-Pei Hsieh, Sandra Wimberger, Saša Šviković, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.

bioRxiv · Feb 1, 2024 · PreprintBioengineering

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, , Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

Nature Communications · Aug 14, 2023Peer-reviewedMolecular Biology

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Dmitrii Degtev, Burcu Bestas, Jack Barr, Stijn van de Plassche, Patricia Mendoza-García, Saša Šviković, Grzegorz Sienski, Mike A. Firth, Marcello Maresca

This paper develops two prime editing strategies using DSB repair to improve genomic insertion efficiency and purity, expanding the prime editing toolkit.

Nature Communications · Mar 24, 2022Peer-reviewedMolecular Biology

Timeless couples G quadruplex detection with processing by DDX11 during DNA replication

Letícia Koch Lerner, Sandro Holzer, Mairi Louise Kilkenny, Pierre Murat, Saša Šviković, Davide Schiavone, Alice Bittleston, Joseph D Maman, Dana Branzei, Katherine M. Stott, Luca Pellegrini, Julian E. Sale

The paper identifies a G quadruplex binding domain in Timeless and shows its collaboration with DDX11 to process G4 structures during DNA replication.

bioRxiv · Oct 31, 2019 · PreprintMolecular Biology

S phase R-loop formation is restricted by PrimPol-mediated repriming

Saša Šviković, Alastair Crisp, Sue Mei Tan‐Wong, Thomas A. Guilliam, Aidan J. Doherty, Nicholas J. Proudfoot, Guillaume Guilbaud, Julian E. Sale

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.

The EMBO Journal · Nov 26, 2018Peer-reviewedMolecular Biology