Author

Yuichiro Aiba

Nagoya UniversityORCID 0000-0003-3994-7480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eiichiro MoriiD· 2 shared Hiroyoshi MatsumuraiD· 2 shared Hitoki NanauraiD· 2 shared Honoka Kawamukai· 2 shared Kazuma SugieiD· 2 shared Koichiro IshimoriiD· 2 shared Takeru Uehara· 2 shared Takuya YoshizawaiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Eiichiro MoriORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 3, 2024

Conserved loop of a phase modifier endows protein condensates with fluidity

Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto…·Tomohide Saio

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

DOI 10.1101/2024.07.03.601791

yeastproteomics

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Molecular BiologybioRxivPreprintOct 21, 2019

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara…·Eiichiro Mori

This study shows that PR poly-dipeptides from C9orf72 repeat expansion bind Kapβ2 and disrupt FUS droplet melting, contributing to nucleocytoplasmic transport deficits in ALS.

2 citations

humanproteomics

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