Author

Takeru Uehara

Ritsumeikan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eiichiro MoriiD· 2 shared Hiroyoshi MatsumuraiD· 2 shared Hitoki NanauraiD· 2 shared Honoka Kawamukai· 2 shared Kazuma SugieiD· 2 shared Koichiro IshimoriiD· 2 shared Takuya YoshizawaiD· 2 shared Tomohide SaioiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Eiichiro MoriORCID

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2 papers

Recent·Most cited

Conserved loop of a phase modifier endows protein condensates with fluidity

Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto, Mai Watabe, Ken Morishima, Shunsuke Tomita, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Hiroyuki Kumeta, Hitoki Nanaura, Kotona Kato, Takuya Mabuchi, Yuichiro Aiba, Takeru Uehara, , Tomohide Saio

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

bioRxiv · Jul 3, 2024 · PreprintBiochemistry

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Yuichiro Aiba, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, , Eiichiro Mori

This study shows that PR poly-dipeptides from C9orf72 repeat expansion bind Kapβ2 and disrupt FUS droplet melting, contributing to nucleocytoplasmic transport deficits in ALS.

bioRxiv · Oct 21, 2019 · PreprintMolecular Biology