Bob Meeusen

The paper systematically assesses the function of short linear motifs (SLiMs) by mutating and screening them in human cells, identifying essential SLiMs for cell proliferation and uncovering novel classes and binding partners.

The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.

This study identifies catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis using CRISPR screening and TLS analysis.