Benilde Jiménez

Transcriptomic profile of embryoid bodies under hypoxia at single cell level

The paper generates a single-cell transcriptomic dataset of murine embryoid bodies under hypoxia and normoxia to study oxygen's impact on lineage specification and cellular heterogeneity during early development.

Bhlhe40 limits proliferation and prevents excessive angiogenesis in mouse embryoid bodies under hypoxia

Metabolic labelling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels

This study uses metabolic labeling to quantify how hypoxia affects RNA levels through transcription and decay rates, finding that transcription is the main driver but degradation also contributes significantly.

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

The paper identifies SIN3A's role in hypoxia-induced transcriptional changes, showing it represses 75% of hypoxia-repressed genes and inhibits 47% of hypoxia-induced genes.