Francisco J. Cimas

Revisiting AXL as a therapeutic target in soft tissue sarcoma: transcriptomic profiling reveals largely AXL-independent activity of dubermatinib and bemcentinib

This study shows that AXL inhibitors dubermatinib and bemcentinib have antitumour effects in soft tissue sarcoma that are largely independent of AXL inhibition.

VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma

This study identifies VCAN as a novel transcriptional target of ERK5 and shows its essential role in ERK5-driven tumorigenesis in soft tissue sarcoma.

The signaling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence.

This paper shows dinaciclib increases radiosensitivity in some cancer cell lines by inhibiting CDK12, reducing BRCA1, and promoting p53-dependent senescence.