Michael J. Notaras

This paper analyzes the evolutionary history of BDNF across 160 mammalian species, finding strict purifying selection in the NGF domain and coevolving sites in the prodomain, linking these findings to disease relevance.

This study uses patient-derived cerebral organoids to identify molecular and cellular mechanisms of Schizophrenia, revealing altered neuronal programming factors and growth factors like BRN2 and PTN.

This paper reports a proteomic analysis of schizophrenia patient-derived cerebral organoids, identifying 43 up-regulated and 54 down-regulated proteins, including GWAS factors and neuronal development-related proteins.

This study shows that astrocytes from ASD patients induce repetitive behavior and impair memory when transplanted into healthy mice, suggesting a primary role for astrocytes in ASD.

This study shows that NMD regulates synaptic plasticity and cognitive function by controlling GluR1 levels through local mRNA degradation and synthesis in dendrites.