Haoyun Fang

This study identifies mechanosensory pathways in monocytes exposed to pathological shear stress, revealing PKC and Piezo1 as key regulators of monocyte phenotype and function in calcific aortic valve disease.

The paper develops a human cardiac microtissue model to study ischemia-reperfusion injury and shows that nanovesicles improve cardiomyocyte survival and function through proteomic changes.

This paper develops a dual-omics workflow to map subcellular proteome and lipidome in mouse heart, revealing sex-dependent molecular differences and conserved subcellular lipid features.

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

This paper reports a proteomic analysis of schizophrenia patient-derived cerebral organoids, identifying 43 up-regulated and 54 down-regulated proteins, including GWAS factors and neuronal development-related proteins.