Francesco Longo

Cell type-specific disruption of cortico-striatal circuitry drive repetitive patterns of behaviour in fragile X syndrome model mice

The paper investigates how cell-type-specific disruptions in cortico-striatal circuits in FXS model mice lead to repetitive behaviors and identifies potential therapeutic targets.

Astrocytes derived from ASD patients alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

This study shows that astrocytes from ASD patients induce repetitive behavior and impair memory when transplanted into healthy mice, suggesting a primary role for astrocytes in ASD.

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice

The paper shows that reducing S6K1 corrects translation defects in FXS mice by normalizing ribosome translocation and translation efficiency across mRNA lengths.

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease

This study shows that reducing eIF2-P in Alzheimer's mouse models improves protein synthesis, synaptic plasticity, and memory.

Genetic reduction of PERK-eIF2α signaling in dopaminergic neurons drives cognitive and age-dependent motor dysfunction

This study shows that reducing PERK-eIF2α signaling in dopaminergic neurons causes cognitive and age-related motor issues in mice.

Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory

The paper develops a chemogenetic tool to inhibit protein synthesis in specific neurons and shows it is required for long-term memory consolidation.

Compartmentalized nonsense-mediated mRNA decay regulates synaptic plasticity and cognitive function via GluR1 signaling

This study shows that NMD regulates synaptic plasticity and cognitive function by controlling GluR1 levels through local mRNA degradation and synthesis in dendrites.