Friederike Dündar

Lysosome-dependent nutrient scavenging underliesstress adaptation during epithelial-to-mesenchymaltransition

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

Activation of an injury-associated transient progenitor state in the epicardium is required for zebrafish heart regeneration

The paper identifies a transient epicardial progenitor cell population in zebrafish that is essential for heart regeneration through single-cell RNA sequencing and functional analysis.

Molecular specification of cortico-brainstem versus corticospinal projection neurons in development

The paper identifies molecular markers distinguishing cortico-brainstem and corticospinal projection neurons during development using single-cell RNA sequencing.

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids

This study uses patient-derived cerebral organoids to identify molecular and cellular mechanisms of Schizophrenia, revealing altered neuronal programming factors and growth factors like BRN2 and PTN.

Epigenetically bistable regions across neuron-specific genes govern neuron eligibility to a coding ensemble in the hippocampus

The paper identifies epigenetically bistable regions in neuronal genes that influence neuronal eligibility for coding ensembles in the hippocampus, showing their role in spatial memory and excitability.