Ting-Wen Chen

The paper characterizes hepatoblastoma with carcinoma features (HBCs) using multi-omics data, revealing their heterogeneous composition, worse outcomes, and origin from arrested HB cells due to WNT signaling.

This study compares the genomics of seven Trichomonas species, revealing convergent genome size expansions in human-infecting lineages and genes involved in host-switching from birds to humans.

The paper identifies lncRNAs that coordinately regulate both transcription and post-transcriptional processing of their targets, showing tight coupling between lncRNA and target abundance, with implications for cancer gene regulation.

This study investigates the role of human DCP1 paralogs in mRNA decapping and reveals their distinct gene regulatory functions through transcriptome and metabolome analyses.

The paper presents a comprehensive human transcriptome atlas with single-nucleotide resolution, identifying thousands of novel RNA species and regulatory interactions.