Chung-Te Chang

The Filterprep: A Simple and Efficient Approach for High-Yield, High-Purity Plasmid DNA Purification

The paper introduces Filterprep, a method for high-yield, high-purity plasmid DNA purification that is faster, cheaper, and more transparent than commercial kits.

Coordinated regulation by lncRNAs results in tight lncRNA-target couplings

The paper identifies lncRNAs that coordinately regulate both transcription and post-transcriptional processing of their targets, showing tight coupling between lncRNA and target abundance, with implications for cancer gene regulation.

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

This study investigates the role of human DCP1 paralogs in mRNA decapping and reveals their distinct gene regulatory functions through transcriptome and metabolome analyses.

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

This study identifies how PUM1 and PUM2 regulate gene expression by interacting with the CCR4-NOT complex and DCP2 to repress mRNA decay.

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs.

This study identifies that Pumilio's repression domains use deadenylation and decapping factors to accelerate mRNA degradation in Drosophila.