Author

William Cairns

Manchester Academic Health Science Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Andreas ProkopiD· 3 shared Milli Owens· 3 shared Yu-Ting Liew· 3 shared André VoelzmanniD· 2 shared Ella Jones· 2 shared Lydia Lorenzo-Cisneros· 2 shared Maureece Day· 2 shared Abigail Elliot· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

Andreas ProkopORCID

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3 papers

Recent·Most cited

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegeneration

André Voelzmann, Milli Owens, Robin Beaven, William Cairns, Abigail Elliot, Sheng-Hui Feng, Judith B. Fülle, Catarina Gonçalves‐Pimentel, Ines Hahn, Ella Jones, Kodie Norris, Yu-Ting Liew, Lydia Lorenzo-Cisneros, Lucy O'Donoghue, Liliana M. Pinho-Correia, , Andreas Prokop

The paper identifies microtubule-curling as a marker of axonal atrophy by analyzing gene deficiencies in Drosophila neurons, revealing two distinct mechanisms linked to neurodegeneration.

bioRxiv · Jun 27, 2025 · PreprintCell Biology

Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration

Scott Murray-Cors, Milli Owens, Yu-Ting Liew, Maureece Day, William Cairns, Andreas Prokop

The paper assesses the impact of 13 mitochondrial factors on axonal microtubule organization in Drosophila neurons to identify mechanisms linking mitochondrial dysfunction to neurodegeneration.

bioRxiv · May 11, 2025 · PreprintCell Biology

Different mechanisms link gain and loss of kinesin functions to axonal degeneration

Yu-Ting Liew, David M. Bailey, William Cairns, Maureece Day, Federico Dajas‐Bailador, Ella Jones, Sophie McCann, Matthias Landgraf, Lydia Lorenzo-Cisneros, Thomas Murphy, Milli Owens, Devesh C. Pant, Jill Parkin, Haydn Tortoishell, André Voelzmann, Andreas Prokop

The paper investigates how both loss and gain of kinesin functions lead to axonal degeneration through microtubule curling in Drosophila neurons.

bioRxiv · Dec 31, 2024 · PreprintNeuroscience