Author

Jamie C Little

University of ZurichORCID 0000-0003-4068-4542Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel KalderoniD· 2 shared Amanda Sul· 1 shared Bryna Patel· 1 shared Elisa García-GarcíaiD· 1 shared H.-Y. KimiD· 1 shared Jason LiiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersDevelopmental Biology

Daniel KalderonORCID

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintJan 24, 2025

Physiological analysis of the mechanism of Ci transcription factor activation through multiple Fused phosphorylation sites in Hedgehog signal transduction

H.-Y. Kim, Jamie C Little, Jason Li…·Daniel Kalderon

The paper investigates how phosphorylation sites on Ci regulate its activation in Drosophila through interactions with Fu kinase and Su(fu), revealing new insights into Ci conformation and activation mechanisms.

DOI 10.1101/2025.01.24.634727

Drosophilaexperimental assay

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Developmental BiologyeLifePeer-reviewedOct 21, 2020

Drosophila Hedgehog can act as a morphogen in the absence of regulated Ci processing

Jamie C Little, Elisa García-García, Amanda Sul, Daniel Kalderon

This study shows that Drosophila Hedgehog can function as a morphogen without requiring regulated Ci processing, as Ci variants resistant to processing support normal gene activation and wing development.

14 citations

Drosophilaprotein structure

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