BiophysicsCellPeer-reviewed
De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy
Ryan W. Mahling, Bence Hegyi, Erin R. Cullen…·Manu Ben Johny
This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.
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