Donald M. Bers

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

This study shows that increased QT interval variability (QTV) can precede early afterdepolarizations (EADs) due to intrinsic dynamical instability in cardiac cells, offering an early warning signal for arrhythmia risk.

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.

The paper shows that Alpha-Actinin-1 enhances CaV1.2 channel activity by localizing it to specific sites and increasing its open probability.