Bence Hegyi

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

This study shows that increased QT interval variability (QTV) can precede early afterdepolarizations (EADs) due to intrinsic dynamical instability in cardiac cells, offering an early warning signal for arrhythmia risk.

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.