Christopher D. Makinson

This paper introduces a new optical framework and imaging devices that enable scalable, high-resolution, multi-immersion light-sheet microscopy for biological samples.

This study identifies local thalamic interneurons as critical for regulating spindles and sleep-dependent learning by modulating thalamocortical activity.

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

The paper develops STARFISH to visualize endogenous Tau translation and degradation in neurons, revealing spatial regulation and neuroproteasome-mediated degradation of Tau in dendrites.

The paper uses two-photon imaging and electrophysiological recordings to study dendritic membrane potential dynamics in mouse hippocampal pyramidal cells during behavior, revealing spatial and temporal patterns of electrical signaling.

This paper introduces a method to reversibly control neuronal activity using a light-activated saxitoxin inhibitor, demonstrating its effectiveness in altering behavior in zebrafish without genetic modification.

This paper introduces positively tuned GEVIs that enhance spike detection in vivo with standard imaging systems, offering higher temporal resolution than calcium indicators.

This study develops a photocaged saxitoxin derivative to precisely control voltage-gated sodium channel blockade and demonstrates its effects on action potential propagation in neurons.