Harley Edwards

This study shows that suppressing asexual development in Aspergillus nidulans improves the mechanical strength of mycelial materials, with some mutants also showing increased elasticity due to autolysis.

This paper develops a live-cell imaging system to study actin dynamics in Aspergillus nidulans, revealing distinct growth phases and actin redistribution during septum formation.

This study uses DIA-PASEF proteomics to identify iron stress responses and siderophore biosynthesis in A. nidulans, revealing MpkA-dependent changes in protein expression and phosphorylation.

This study shows that inhibiting asexual development in Aspergillus nidulans with DFMO increases mycelial material tensile strength, with the highest effect at 5 mM DFMO.

The paper demonstrates a method using LSTM networks to generate dynamic omics data, showing it can predict biological responses with few samples and uncovering a paradoxical BrlA response to micafungin.

This study shows that deleting the MpkA kinase in Aspergillus nidulans alters mycelial material mechanical properties, including increased tensile strength and resistance to fragmentation.

This study identifies crosstalk between the CWI and SIN pathways in fungi, showing that it enables hyperseptation under echinocandin stress, which contributes to resistance.

This paper shows BrlA in Aspergillus nidulans regulates cell-wall stress response independently of conidiation, identifying genes involved in transport and secondary metabolism.

This paper introduces derivative profiling (DP) to identify differentially changing signals in dynamic omics data, showing it is statistically comparable to existing methods and computationally efficient.

This paper optimizes CRISPR-Cpf1 for genome editing in Yarrowia lipolytica, achieving high editing efficiencies for multiple targets.