Peng Xu

This paper introduces an ultrasound-responsive gene regulation system in bacteria that uses an AND-gate mechanism combining ultrasound and rapamycin to control gene expression in a microbial consortium.

This study engineers Escherichia coli to de novo synthesize estragole and anethole, achieving 246.88% and 202.44% increases in production compared to initial strains.

The paper engineers two malonyl-CoA pathways in Yarrowia lipolytica using amino acids to boost polyketide production, achieving 6.4 g/L of a new polyketide.

This study evaluates the toxicity of methanol, formaldehyde, and formate on Yarrowia lipolytica growth, finding varying tolerance levels and demonstrating formate's utility in improving lipid production.

This paper demonstrates the de novo biosynthesis of cannabinoids and their analogs in Yarrowia lipolytica through metabolic engineering.

This paper evaluates genetically-encoded reporters in Yarrowia lipolytica, finding that mScarlet-I3 and Nanoluc luciferase provide the highest signal/noise ratios for gene expression studies.

This study improves the biosynthesis of the cannabinoid precursor olivetolic acid in Yarrowia lipolytica by overcoming rate-limiting steps, achieving an 83-fold increase in OLA titer.

This paper engineers Yarrowia lipolytica to produce five aromatic chemicals and natural products by modifying the shikimate pathway and blocking competing pathways.

This paper improves strain stability and pathway yield in engineered yeast by coupling metabolic addiction with negative autoregulation.

The paper develops a computational framework to analyze a synthetic malonyl-CoA switch in E. coli, identifying design principles that enhance fatty acid production.

This paper optimizes CRISPR-Cpf1 for genome editing in Yarrowia lipolytica, achieving high editing efficiencies for multiple targets.

This study optimizes Y. lipolytica for producing flavonoids and hydroxylated flavonoids by engineering metabolic pathways and enzyme modules.