Federica Cella

Engineering Cybergenetic Cell-Based Therapies

This paper develops a control-theoretic framework for engineering closed-loop cell-based therapies using nullgram profiling and a digital twin platform to achieve robust regulation of cellular behavior.

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

Characterization, modelling and mitigation of gene expression burden in mammalian cells

This study identifies gene expression burden in mammalian cells and introduces miRNA-based circuits to mitigate it, improving synthetic circuit performance.