Author

M. H. Chen

ETH Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Claveras Cabezudo· 1 shared A. S. I. Cook· 1 shared A. T. Iavarone· 1 shared Asterios ArampatzisiD· 1 shared Ching-Hsiang ChangiD· 1 shared D. Yang· 1 shared Federica CellaiD· 1 shared G. Chen· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. Claveras Cabezudo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering Cybergenetic Cell-Based Therapies

Ching-Hsiang Chang, Asterios Arampatzis, Samuel Balula, Mucun Hou, Maurice Filo, M. H. Chen, Federica Cella, Mustafa Khammash

This paper develops a control-theoretic framework for engineering closed-loop cell-based therapies using nullgram profiling and a digital twin platform to achieve robust regulation of cellular behavior.

bioRxiv · Jan 19, 2026 · PreprintSynthetic Biology

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

A. S. I. Cook, M. H. Chen, X. Ren, S. Rao, S. N. Garcia, A. Claveras Cabezudo, A. T. Iavarone, G. Hummer, J. H. Hurley

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

bioRxiv · Sep 28, 2023Biochemistry

Targeting intracellular Neu1 for Coronavirus Infection Treatment

D. Yang, Y. Wu, I. Turan, J. Keil, K. Li, M. H. Chen, R. Liu, L. Wang, X.-L. Sun, G. Chen

This study identifies Neu1 as a therapeutic target for coronavirus infection by showing its role in sialylation of viral proteins and demonstrates that a Neu1 inhibitor reduces viral replication in vitro and in vivo.

bioRxiv · Sep 9, 2022Microbiology