Jin Seok Lee

This study identifies a stable immunodominance hierarchy of tumor antigens in a murine bladder cancer model under anti-PD1 and anti-CTLA4 therapy, suggesting broad antigen selection could improve immunotherapy.

ACE optimizes ELISpot assay design by using an epitope similarity model to reduce false positives and improve efficiency.

Destin2 improves cross-modality analysis of scATAC-seq data by integrating multiple epigenomic features for dimension reduction, clustering, and trajectory inference.

This study uses a multi-omic approach to analyze complex genomic rearrangements in head and neck cancers, identifying HPV-mediated instability and enhancer hijacking as drivers of oncogene overexpression.