Alex M. Jaeger

The paper introduces RyboCypher, a platform that maps the dark transcriptome to unannotated peptides, identifying cryptic proteins in cancer cell lines, tumors, and healthy tissues.

This study identifies circPMS1 as a pro-metastatic circRNA in melanoma that promotes cytoskeletal remodeling and metastasis by scaffolding LIM proteins.

This study identifies a stable immunodominance hierarchy of tumor antigens in a murine bladder cancer model under anti-PD1 and anti-CTLA4 therapy, suggesting broad antigen selection could improve immunotherapy.

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.

The paper introduces a method to spatially label and isolate cells using photoactivatable dyes, demonstrating its application in organoids and tissue sections to study spatial gene expression and cell behavior.