Author

Elena Simonazzi

UK Dementia Research InstituteORCID 0000-0003-4166-704XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Philip R. TayloriD· 2 shared Adam RansoniD· 1 shared B. Paul MorganiD· 1 shared Emily MaguireiD· 1 shared Fangli Chen· 1 shared Frank SengpieliD· 1 shared Joshua O Stevenson‐HoareiD· 1 shared Julie H. WilliamsiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Philip R. TaylorORCID

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2 papers

Recent·Most cited

Uncoupling of synaptic loss from amyloid burden by an Alzheimer's disease protective variant of PLCγ2.

Ryan J. Bevan, Emily Maguire, Tom J. Phillips, Elena Simonazzi, Marieta Vassileva, Julie H. Williams, Philip R. Taylor

This study identifies a protective PLCG2 variant that preserves synaptic integrity and reduces microglial synapse engulfment in Alzheimer's disease, independent of amyloid burden.

bioRxiv · Sep 22, 2023 · PreprintNeuroscience

Abi3 regulates microglial ramification and dynamic tissue surveillance in vivo.

Elena Simonazzi, Ruth E. Jones, Fangli Chen, Adam Ranson, Joshua O Stevenson‐Hoare, Valentina Escott‐Price, Frank Sengpiel, B. Paul Morgan, Philip R. Taylor

This study shows Abi3 is essential for microglial morphology, distribution, and tissue surveillance in vivo, linking it to Alzheimer's disease risk.

bioRxiv · Mar 19, 2021 · PreprintNeuroscience