Anna E. Beaudin

Developmental IL7/IL7R signaling in fetal resident tissue macrophages regulates adaptive responses to liver injury

This study shows that IL7/IL7R signaling during fetal development programs liver-resident macrophages, which are critical for postnatal immune responses to liver injury.

Maternal Folate Nutrition Programs Adult Hematopoietic Stem Cell Function Through Mitochondrial Remodeling

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosis

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

Tn5Prime, a Tn5 based 5’ Capture Method for Single Cell RNA-seq

Tn5Prime is a 5' capture method for RNA-seq that enables accurate transcription start site identification and transcriptome quantification in single cells and bulk samples.

Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation Among the Surface Receptors of Individual B cells

The paper uses long-read RNAseq to identify and quantify complex isoforms in individual B cells, revealing widespread transcriptional variation in surface receptors and the antibody heavy chain locus.