Author

Alexander C. Nelson

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro BarreraiD· 2 shared Andrew S. AlleniD· 2 shared Charles A. GersbachiD· 2 shared Gregory E. CrawfordiD· 2 shared Julia W. RileyiD· 2 shared Marisa C. HamiltoniD· 2 shared Sophie F. Dornbaum· 2 shared Aaron A Coley· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alejandro BarreraORCID

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2 papers

Recent·Most cited

Interrogation of noncoding schizophrenia risk variants using CRISPR-based functional genomics

Marisa C. Hamilton, Julia W. Riley, Alexander C. Nelson, Boxun Li, Sophie F. Dornbaum, Alexias Safi, Xiekui Cui, Ian Richard Jones, Aaron A Coley, Kevin T. Hagy, Ruhi Rai, Alejandro Barrera, Andrew S. Allen, Yin Shen, Richard I. Sherwood, , Gregory E. Crawford

The paper uses CRISPR-based functional genomics to identify noncoding regulatory elements and variants affecting schizophrenia-associated gene expression.

bioRxiv · Sep 17, 2026 · PreprintGenomics

Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER

Siyan Liu, Marisa C. Hamilton, Thomas Cowart, Alejandro Barrera, Lexi R. Bounds, Alexander C. Nelson, Sophie F. Dornbaum, Julia W. Riley, Richard W. Doty, Andrew S. Allen, Gregory E. Crawford, William H. Majoros, Charles A. Gersbach

The paper develops CLEANSER, a model to filter ambient gRNAs in single-cell CRISPR screens, improving gRNA-cell assignment accuracy and differential gene expression analysis.

Cell Genomics · Feb 1, 2025Peer-reviewedGenomics