Tong Wang

This paper develops beCasKAS, a method to directly detect off-target base editor activity in primary cells, revealing distinct off-target profiles and enabling risk stratification of edits.

The paper introduces a high-resolution single-molecule chromatin accessibility mapping method to quantify transcription factor occupancy and co-accessibility in human cell lines.

This study develops snhmC-seq to quantify 5hmC in single cells and identifies non-canonical gene regulation by non-CG 5hmC in mouse brain.