Mayra L. Ruiz Tejada Segura

AtlasOT improves multimodal integration of disease atlases by addressing unpaired data constraints through a novel optimal transport framework.

This study identifies Spp1⁺ macrophages as key hubs coordinating fibrotic remodeling in myeloproliferative neoplasms using NicheSphere, a novel computational method for cell communication analysis.

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.

CIARA identifies markers of rare cell types from single-cell RNA-seq data, outperforming existing methods and discovering new cell populations in mouse and human samples.

This paper creates a 3D spatial transcriptomics atlas of the mouse olfactory mucosa, revealing spatial gene distribution patterns and supporting the chromatographic theory of olfaction.

The paper examines gene expression changes across multiple organs during short-term fasting in mice, identifying a brain-liver-fats network with significant immune system regulation.